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Search results - Stem Cells: A Pathway Through the Maze
Course details
Key facts
| Types | Professional Development Short Courses |
|---|---|
| Location | Oxford |
| Address | Rewley House OX1 2JA map |
| Dates | Wed 11 to Fri 13 Dec 2013 |
| Subject area(s) | Biological Sciences |
| Fees | From £945.00 |
| Application status | Applications being accepted |
| Course code | O13C496C1Y |
| Course contact | If you have any questions about this course, please email cpdbio@conted.ox.ac.uk. |
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Overview
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Twenty lecture and discussion sessions which bring together eighteen of the leading experts in the field to explore this cutting-edge technology.
Note: This is a two-day course held over three days - from lunchtime on Wednesday until lunchtime on Friday.
For details of the Oxford Vaccinology Programme, click here.
Description
Few topics have captured the imagination of the general public quite as dramatically as stem cells, both for the potential they offer regenerative medicine and the ethical sensitivities they create.
This course is intended to dispel the myths behind stem cell biology and introduce delegates to the science behind the headlines, the pitfalls as well as the promises.
Although the course will assume basic knowledge of the biomedical sciences, no previous understanding of stem cell biology will be required.
“The course is designed for those who have little prior knowledge or understanding of stem cells, so as to provide as broad an overview of the subject as possible. This will include not only the science underlying the subject but related issues such as the ethics and regulatory infrastructure and commercialisation of regenerative medicine.
Many of the lecturers will undoubtedly present some of their more cutting-edge insights which will, we hope, be of relevance to those with a particular interest in the field and who already come with specialist knowledge. In essence, we therefore hope to cater for the range of people we anticipate will be attracted to the course."
Dr Paul Fairchild, Co-Director, Oxford Stem Cell Institute, University of Oxford
Watch this short video for a taster of the course.
What people say about the course
"Well-organised, very valuable and scientifically
interesting. Gives materials for future in-depth
study."
Carla Martino, Scientific Administrator, The European Medicines
Agency (EMEA)
"Fantastic review of current status of field in an
informative and understandable format."
Rebecca Dias, Head of In Vivo Pharmacology, Pfizer Ltd
"An excellent overview of the field."
Una Riekstina, University of Latvia
"An interesting and stimulating course - helps me
understand the current position of stem cell
research."
Pilar Vazquez, D.Phil student, University of Oxford
Programme details
Please note that the below course programme, along with the course presenters may be subject to change.
The course will begin by introducing key concepts in the field which will form the basis for exploring the properties of selected populations of adult and embryonic stem cells.
Later sessions will be devoted to applied topics that are essential to the therapeutic application of stem cell biology before focussing on ethical and regulatory issues and surveying the landscape for patenting and marketing of stem cell therapies.
The taught component of the course will draw on the varied expertise available within the University of Oxford, with contributions from outside experts, where appropriate.
This course is led by Dr Paul Fairchild, Co-Director, Oxford Stem Cell Institute, Sir William Dunn School of Pathology, University of Oxford.
Schedule
The details below are provisional and may be subject to change.
Day 1: Afternoon Session - Basics of Stem Cell Biology
Welcome tea/coffee
14:00 Stem Cells: Definitions and Principles
Dr Paul Fairchild, Sir William Dunn School of Pathology,
University of Oxford
14:40 Molecular Mechanisms of Pluripotency
Dr Ita Costello, Sir William Dunn School of Pathology,
University of Oxford
15:20 Induced Pluripotency and Reprogramming
Dr Lee Carpenter, Nuffield Dept of Clinical Laboratory Sciences
16:00 Afternoon tea/coffee
16:20 Small Molecule Manipulation of Stem Cell
Fate
Dr Angela Russell, Depts of Chemistry and Pharmacy
17:00 Stem Cells in the Eye
Professor Robert MacLaren, Nuffield Laboratory of Ophthalmology
17:40 Finish
Day 2: Morning Session - Stem Cell Populations: Adult versus Embryonic
9:00 The Stem Cell Niche
Dr Carolyn Carr, Dept of Physiology, Anatomy and Genetics
9:40 Hematopoietic Stem Cells
Dr Marella de Bruijn, Weatherall Institute of Molecular
Medicine
10:20 Neural Progenitors and Stem Cells
Professor Zoltan Molnar, Dept Physiology, Anatomy and Genetics
11:00 Morning tea/coffee
11:30 Cardiac Stem Cells
Professor Paul Riley, Dept of Physiology, Anatomy and Genetics
12:10 Embryonic Stem Cells
Dr Frances Brook, Nuffield Dept of Obstetrics and Gynaecology
12:50 Lunch
Day 2: Afternoon Session - Applied Topics in Stem Cell Biology
14:00 Reprogramming Technologies for Neurodegenerative
Research
Dr Elizabeth Hartfield, Dept of Physiology, Anatomy and
Genetics
14:40 Stem Cells and Gene Therapy
Prof Len Seymour, Dept of Clinical Pharmacology
15:20 Is Cancer a Stem Cell Disease?
Prof Colin Goding, Ludwig Institute
16:00 Afternoon tea/coffee
16:20 Stem Cells and Epigenetics
Professor Udo Oppermann, Dept of Orthopaedics, Theumatology
& Musculoskeletal Sciences
17:00 Advances in Tissue Engineering
Dr Xuan Du, Dept of Materials
17:40 Finish
Day 3: Morning Session - Barriers to Regenerative Medicine: Scientific, Ethical and Regulatory Issues
9:00 Circumventing Immunogenicity in Stem Cell
Therapies
Dr Paul Fairchild, Sir William Dunn School of Pathology
9:40 Killing embryos for stem cell research
Dr Katrien Devolder, Programme on Ethics of the New Biosciences
10:20 Commercialisation of Stem Cell Biology
Dr Zoe Li, Zyoxel Ltd, Oxford University Begbroke Science Park
11:00 Morning tea/coffee
11:30 Intellectual Property Rights and Patenting of Stem
Cells
Dr Lee Chapman, J A Kemp & Co Chartered Patent Attorneys,
London
12:10 Legal and Regulatory Aspects of Stem Cell
Biology
Professor Glyn Stacey, UK Stem Cell Bank, South Mimms
12:50 Finish
Staff
Dr Paul Fairchild
Role: Director
After obtaining a first class...more degree and an award for top graduate in the Biological Sciences, Paul Fairchild began his research career in Oxford, where he studied for a DPhil within the Nuffield Department of Surgery, focussing on the immune response to organ allografts.
After spending five years as a Post-Doctoral Fellow in the Department of Pathology, University of Cambridge, he returned to Oxford where he is currently a Lecturer and RCUK Academic Fellow within the Sir William Dunn School of Pathology. Here, he has applied his immunological training to the emerging field of cell replacement therapy and regenerative medicine to investigate the immune response to tissues differentiated from embryonic stem cells, the rejection of which threatens to undermine the success of regenerative medicine in the future.
He has developed technologies which may help promote the indefinite survival of stem cell-derived grafts, which forms the basis of a patent, licensed by Geron Corporation with whom he collaborates scientifically. He has published widely in the field and is a frequent speaker at international conferences.
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Dr Frances Brook
Role: Speaker
Dr Brook completed a D.Phil at Oxford in the Department of...more Agricultural Sciences, studying ovarian structure and function in the wood mouse, Apodemus sylvaticus. Following a post-doctoral position at Washington University in St. Louis she returned to Oxford to work on post-implantation mouse embryo development with Dr Andrew Copp. Subsequently she joined the laboratory of Professor Sir Richard Gardner to study the biology of mouse embryonic stem cells, work that involved the derivation of numerous new ES cell lines. She then moved to the in Nuffield Department of Obstetrics & Gynaecology to work in the laboratory of Professor Helen Mardon on a project to derive human embryonic stem cells. Currently she is in the Department of Cardiovascular Medicine in Professor Hugh Watkins’ group working on a project to derive patient-specific iPS cells and to differentiate these into cardiomyocytes.
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Dr Lee Carpenter
Role: Speaker
After obtaining an Hons...more Degree in Biological Sciences at the University of Leicester, and a PhD in Biochemistry at the University of Bristol, I spent my first post-doc at the Garvan Institute for Medical Sciences in Sydney, Australia, studying aspects of insulin secretion in Diabetes, and is where I became interested in pancreatic stem cells.
I returned to the UK to further my interests in stem cell biology, where within the Department of Genetics, University of Cambridge, I undertook projects in cancer and stem cell biology, using novel technologies to understand aspects of cell cycle regulation and stem cell fate determination. Now working within the NDCLS, University of Oxford, and NHS Blood and Transplant, I am focused on using induced pluripotent stem cells to ask novel questions in early haematological development, ultimately with a view to applying this towards generating clinical grade blood products for transfusion medicine. I was the first in Oxford to generate human iPS cells, and have now developed an extensive network of collaborators in Oxford and nationally, with a view to demonstrating their clinical potential, and with which to understand concepts in early haematopoietic development.
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Dr Carolyn Carr
Role: Speaker
Carolyn Carr is a senior...more post-doctoral research fellow in the Department of Physiology, Anatomy and Genetics at the University of Oxford. She has a DPhil in Chemistry from Oxford and has worked with NMR spectroscopy and mass spectrometry both within the Chemistry Department at Oxford and also in industry for Kodak Ltd and Synaptica Ltd. She had a career break of 10 years to spend time with her children and returned to science with a Daphen Jackson Returner’s Fellowship. Since joining Professor Kieran Clarke’s group in 2003 she has progressed from Chemistry to Biology, as she now runs their BHF funded project, studying stem cell therapy for the infarcted heart. She uses her MR skills to measure cardiac function before and after stem cell therapy and to track the cells in vivo. As well as presenting her work at conferences, she enjoys giving ‘public understanding of science’ lectures about stem cell therapy.
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Dr Lee Chapman
Role: Speaker
Dr Lee Chapman has a Degree in Physiological Sciences from the University of...more Oxford and was awarded his DPhil from the same institution, focusing on the endocrine regulation of reproduction during stress. He joined J A Kemp & Co in 2002 and qualified as a patent attorney in 2005.
Lee deals with a wide variety of biotechnology subject matter, with areas of particular expertise including stem cells, therapeutic cloning, Alzheimer's disease, molecular biology, multiplex assays and diagnostics. He has experience in various patent-related matters, including drafting patent applications, prosecution of patent applications in Europe and other territories, and European Patent Office (EPO) oppositions and appeals. Lee also has experience in carrying out freedom to operate and due diligence exercises. Lee was part of the team that represented WARF in front of the Enlarged Board of Appeal of the EPO. He often works from J A Kemp & Co’s Oxford office where his clients include Isis Innovation Ltd and Oxford Nanopore Technologies Ltd.
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Dr Ita Costello
Role: Speaker
I attended the National University of Ireland, Galway where I...more obtained a B.Sc (Hons) degree in Biotechnology. Following this I undertook a four-year Wellcome Trust funded PhD in the cellular and molecular basis of disease at the University of Edinburgh. After completing my M.Sc. degree in my first year, I conducted my PhD at the Institute of Stem Cell Research.
My PhD research focused on the area of transcriptional regulation in embryonic stem cell maintenance, in particular the role chromatin remodeling and histone modifications plays in ES cell pluripotency and in early mammalian development.
I joined the lab of Prof. Elizabeth Robertson at the Sir William Dunn School of Pathology, University of Oxford in 2008, where my post-doctoral research has focused on exploiting mouse genetics to investigate the molecular mechanisms underlying mammalian development, specifically understanding the transcriptional control of early lineage decisions.
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Dr Marella de Bruijn
Role: Speaker
Marella de Bruijn obtained her PhD from Erasmus University,...more Rotterdam, the Netherlands, where she trained in immunology and hematology. She then was a post-doctoral fellow in the Department of Cell Biology and Genetics at Erasmus University, and a fellow of the Dutch Cancer Society in the Department of Biochemistry at Dartmouth Medical School, Hanover, NH. She moved to Oxford to join the faculty of the MRC Molecular Haematology Unit in 2003, where she is currently a tenured Group Leader, and an associate of the Oxford Stem Cell Institute. Her research interest is directed towards elucidating the cellular and regulatory processes that give rise to hematopoietic stem cells (HSCs) during embryogenesis, with the aim to better understand the transcriptional network that underlies de novo HSC generation. Her work is relevant to future studies aimed at generating/expanding HSCs in the clinic, and could provide a framework to explore the changes in the network associated with leukemia.
Areas of expertise: Stem cells, developmental hematopoiesis, transcriptional regulation.
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Dr Katrien Devolder
Role: Speaker
Katrien Devolder's research interests lie in applied ethics, more particularly in the ethics of the new biosciences: stem cell research, cloning and genetics. She has published extensively on these issues in the most important international peer-reviewed journals in bioethics as well as in science journals. She is the author, together with Johan Braeckman, of a monograph on the ethics of human cloning (Leuven University Press 2001), and is currently finalizing a book in which she criticizes the most popular compromise positions in the embryonic stem cell debate (OUP).
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Prof Colin Goding
Role: Speaker
Colin Goding graduated from the University of Leeds, UK after studying microbiology, and subsequently entered...more the 3 year PhD program at the UK Medical Research Council’s National Institute for Medical Research in Mill Hill, London where he studied adenovirus DNA replication. He then moved to Pierre Chambon’s lab in Strasbourg, France with a Royal Society Fellowship to investigate the mechanisms underlying adenovirus gene expression. His work there led to him being offered a position to run his own lab at the Marie Curie Research Institute in Surrey, UK where he established a program of research examining basic mechanisms of gene expression in S. cerevisiae and cell type-specific gene expression in melanocytes and melanoma. His work has continued on these two parallel research themes on his move in 2008 to the Ludwig Institute for Cancer Research at the University of Oxford UK. He was Editor-in Chief of Pigment Cell and Melanoma Research from 2005-2010, elected to membership of EMBO in 2009, and became co-director of the Oxford Stem Cell Institute in 2011.
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Dr Elizabeth Hartfield
Role: Speaker
Elizabeth is a molecular and cellular...more biologist who joined the Oxford Parkinson’s Disease Centre (OPDC) in 2010 as a Career Development Fellow. She received her PhD in Molecular Neuroscience from Bristol University in 2010. Her research involves utilising cellular reprogramming technologies to generate induced pluripotent stem cells from Parkinson’s disease (PD) patients and differentiate these into dopaminergic neurons. These cells provide a clinically relevant model for PD and she hopes that these human neurons will aid in the elucidation of the early molecular mechanisms of neurodegeneration involved in this disease. By identifying phenotypes in patient-derived cells, this opens up the opportunity for identifying potential therapeutics for PD.
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Dr Zoe Zhaohui Li
Role: Speaker
Zoe Li was trained as a polymer chemical engineer in...more China and obtained her DPhil on Tissue Engineering in the Department of Engineering at Oxford University, where her study focused on molecular markers for monitoring engineered tissue growth using microdialysis technique.
After spending two years as a Post-Doctoral Researcher in the Nuffield Department of Obstetrics and Gynaecology, Oxford University to develop an in vitro 3D human endometrium model for study stem cells and diseases that result from endometrial dysfunction and infertility, she moved into biotechnology-based, Oxford University spin-out, Zyoxel Ltd. As Head of Biology, her main role is overall responsibility for Zyoxel’s biological works and advancing new areas in three-dimensional (3D) culture. Her primary interest is to develop various in vitro 3D human models using primary cells and human stem cell lines for drug testing. She is currently developing 3D liver co-culture model and 3D iPS-derived hepatocyte models for drug toxicity and efficacy testing.
Zoe has an active publication record focused on the 3D culture of primary cell types and on-line analysis of cell function, and plays scientific/technical roles for business development in China.
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Prof Robert MacLaren
Role: Speaker
Prof Zoltan Molnar
Role: Speaker
Zoltán Molnár obtained his M.D. at the Albert Szent-Györgyi Medical...more University, Szeged, Hungary where he started his residency in Neurological Surgery until he moved to Oxford in 1989. He obtained his D.Phil. at the University Laboratory of Physiology in the laboratory of C. Blakemore studying the multiple mechanisms in the establishment of thalamocortical innervation. He continued his work on cerebral cortical development at Oxford as an MRC training fellow and Junior Research Fellow at Merton College. He also investigated thalamocortical development working with E. Welker at the Institut de Biologie Cellulaire et de Morphologie, Université de Lausanne, Switzerland, and learned optical recording techniques to understand early functional thalamocortical interactions in the laboratory of K. Toyama at Kyoto Prefectural School of Medicine, Japan. He was appointed to a University Lecturer position at the Department of Human Anatomy and Genetics associated with a Tutorship at St John's College, Oxford from 2000.
Zoltán Molnár’s research focus is on the cerebral cortical development. It seeks to decipher how cerebral cortical neural cell fates are determined (with special attention in the earliest generated cells in the subplate and in the large pyramidal cells of layer 5), and how development of cortical functional specialisation (arealization) is determined by genetic and environmental factors. The arealization of the mammalian cortex is believed to be controlled by a combination of intrinsic factors that are expressed in the cortex, and external signals, some of which are mediated through thalamic input. Members of Zoltán Molnár’s research group study the development of the cortical connectivity in this context. Recent studies have identified families of molecules that are involved in thalamic axon growth, pathfinding and cortical target selection, and the mechanisms of cytoarchitectonic differentiation imposed by thalamic projections on the developing cortex. Greater understanding of these basic neurobiological problems could solve numerous questions relating to cortical development as well as to the prevention and treatment of many neurological and psychiatric disorders (e.g. childhood epilepsy, schizophrenia, attention deficit hyperactivity disorder, autism) that affect millions of people of all ages at tremendous cost to the national economy.
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Prof Udo Oppermann
Role: Speaker
The research in the Oppermann group focuses on the biology and structure-activity relationships of human metabolic protein families of all types but with emphasis on oxidoreductases such as short- or medium chain dehydrogenases / reductases (SDR, MDR), or oxidative enzymes such as the ketoglutarate dependent oxygenases. The use of chemical biology to understand human biology is a major focus of the group and is currently applied to the field of epigenetic mechanisms in stem cell biology, as well as chronic inflammatory and metabolic diseases. close
Prof Paul Riley
Role: Speaker
Dr Angela Russell
Role: Speaker
Angela Russell gained an MChem degree from Oxford University in 2000,...more which included a Part II project on the synthesis and evaluation of ion channel mimics under the supervision of Paul Beer. She gained her DPhil from Oxford in 2004 under the joint supervision of Steve Davies and Tim Perera from Yamanouchi plc (now Astellas Pharma Inc.). The main focus of her work was using a pharmacophore modelling approach for the development of novel phosphatase inhibitors but also encompassed the development of novel asymmetric methodologies and the synthesis of molecules of biological importance. In March 2006 she became a Departmental Research Lecturer in Organic Chemistry and in August 2007 was awarded an RCUK Fellowship in Medicinal Chemistry jointly between the Departments of Chemistry and Pharmacology in Oxford.
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Professor Leonard Seymour
Role: Speaker
Professor Len Seymour is a world authority on genetic medicine, with over 120...more publications and several patents. Len is Professor of Gene Therapies, and Director of the Section of Clinical Pharmacology at the University of Oxford’s Department of Oncology. He sits on a number of editorial and scientific advisory boards, was the founding President of the British Society for Gene Therapy, and is the current General Secretary of the European Society of Gene and Cell Therapy.
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Prof Glyn Stacey
Role: Speaker
Glyn Stacey has a background in public health and cancer research and has worked on the...more development of cell substrates for manufacture of biological medicines. He is currently Head of Division of Cell Biology and Imaging and Director for the UK Stem Cell bank, a licensed clinical tissue bank, at the National Institute for Biological Standards and Control at South Mimms, UK. The work of his group covers safety and quality issues in cell therapy, cells used for manufacturing purposes, development of novel cell-based assays and the development of reference materials for tissue typing and diagnosis of genetic disorders. This work includes the need for scale up of preservation techniques and long term storage of DNA and cell lines of various types including human stem cell lines and cells used in bioassays and vaccine production. Glyn serves on numerous steering groups for organisations promoting and funding regenerative medicine and for many years as a committee member for the Society for Low Temperature Biology. He has also chaired the scientific advisory board for a Public Private Partnership not-for-profit company called Stem Cells for Safer Medicine.
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Certification
Sample certificateParticipants who satisfy the course requirements will receive a Certificate of Attendance. The pdf sample above is an illustration only, and the wording will reflect the course and dates attended.
Level and demands
The course is likely to appeal to research scientists from either industrial or academic sectors, considering entering the stem cell field, together with PhD students wishing to gain a thorough understanding of the field at the outset of their studies.
Furthermore, the course may prove beneficial for healthcare professionals, wishing to explore the likely influence that stem cell biology will have on the practice of medicine in the future, as well as those working for regulatory bodies or in related fields such as journalism, for which a firm understanding of the principles of stem cell biology may facilitate future coverage of developments in the field.
"The course is designed for those who have no prior knowledge or understanding of stem cells, so as to provide as broad an overview of the subject as possible. This will include not only the science underlying the subject but related issues such as the ethics and regulatory infrastructure and commercialisation of regenerative medicine.
Many of the lecturers will undoubtedly present some of
their more cutting-edge insights which will, we hope, be of
interest to those with a particular interest in the field and
who already come with specialist knowledge. In essence, we
therefore hope to cater for the range of people we anticipate
will be attracted to the course."
Dr Paul Fairchild
Accommodation
Accommodation is available at the Rewley House Residential Centre, within the Department for Continuing Education, in central Oxford. The comfortable, en-suite, study-bedrooms are rated 3-star, and come with free high-speed internet access and TV. Guests can take advantage of the excellent dining facilities and common room bar, where they may relax and network with others on the programme.
Payment
Fees include course materials, tuition, refreshments and lunches. The price does not include accommodation.
All courses are VAT exempt.
Apply for this course
If you would like to discuss your application or any part of the application process before applying, please contact:
Course Administrator
Tel: +44 (0)1865 286958
Email: cpdbio@conted.ox.ac.uk
You can apply for this course in the following ways:
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Programmes including this module
This module can be studied as part of these programmes:

