Human Genes and their Roles in Viral Infection

Overview

Incapable to do it themselves, viruses completely rely on using human host biology in invading their cells, a process known as infection. It is our own biology controlled by our own genes that allow viruses to infect our body. How does this process take place and what influential factors are involved? In this course, we will reveal some of the molecular events that are involved in viral infection and how our own human genes are involved in this process. An interesting scene from two sides, facilitating viral entry to our cells and also fighting viruses to eradicate their infection.

One of the most crucial biological processes is how we defend ourselves against pathogenic invaders such as viruses. It is logical to assume that in order to invade a very complex organism, such as a human, a similar level of complexity is required. Viruses do just that through their sophisticated genetic system. The irony is that these viruses cannot survive alone and it is the human body that offers them a luxurious hotel in which to stay and multiply.

Viruses such as COVID-19 invade the body and propagate inside it to produce more viruses that spreads from one person to another. COVID-19 specifically, has a very unique speed in invading and infecting humans. This is due to its genetic ability of sticking strongly to the human cell surface.

In this course, we will attempt to understand how viral diseases develop at the molecular level, taking the COVID-19 as an example virus. But before that, we will introduce human genes and their functions. We will then look into more details at how human genes fight virus genes. Finally, we will explore how scientists are developing several approaches in the search for anti-virus therapies.

Programme details

Course starts: 23rd Apr 2024

Week 1: Human cells

Week 2: Human genes

Week 3: Human genes role in diseases

Week 4: Viruses and their genes

Week 5: Viral infections

Week 6: Human genes and anti-viral defence mechanisms

Week 7: COVID-19: virus and disease

Week 8: COVID-19 virus’s unique genetic abilities

Week 9: Human genes fighting COVID-19 virus’s genes

Week 10: COVID-19 therapeutic approaches

Digital Certification

To complete the course and receive a certificate, you will be required to attend at least 80% of the classes on the course and pass your final assignment. Upon successful completion, you will receive a link to download a University of Oxford digital certificate. Information on how to access this digital certificate will be emailed to you after the end of the course. The certificate will show your name, the course title and the dates of the course you attended. You will be able to download your certificate or share it on social media if you choose to do so.

Fees

Description Costs
Course Fee £257.00
Take this course for CATS points £10.00

Funding

If you are in receipt of a UK state benefit, you are a full-time student in the UK or a student on a low income, you may be eligible for a reduction of 50% of tuition fees. Please see the below link for full details:

Concessionary fees for short courses

Tutor

Dr Amr Abdelgany

Amr is an Associate Senior Tutor at the department who has worked on gene therapy since his DPhil at Oxford. He then continued his research at Oxford exploring novel genetic methods for discovery of new therapies. Amr has taught for the department since 2012.

Course aims

To understand human gene’s function and how they act against viral infections focusing on the COVID-19 virus as an example.

Course Objectives:

Understanding the basics about:

  • human genes’ structure and function;
  • viral genes’ structure and viral infection process;
  • COVID-19 uniqueness and why it is so deadly;
  • how scientists search and discover anti-viral therapies.

Teaching methods

The course is delivered using a diverse range of teaching formats, allowing students to be at the centre of directing learning the session contents. In a two-hour session, there will be a PowerPoint presentation lecture introducing and explaining the main content of the lesson, followed by questions and answers (Q&A) session. The Q&A session is an integrated discussion that include contributions from students as well as the tutor. In all sessions, participants are always part of the class and encouraged to engage in discussions. Some session will be in a workshop format where participants will be working on a task in groups, followed by a general discussion. Topic-specific discussion groups is also considered in some of the sessions.

Learning outcomes

By the end of the course students will be expected to:

  • gain a basic knowledge about human genes and their functions in diseases;
  • use the COVID-19 model to gain basic knowledge of how viruses infect human using their genetic makeup;
  • develop skills in how to find out about how genes are involved in any given disease.

Assessment methods

Assessment for this course is based on two written assignments (with a total of 1500 words). Students will have about two weeks to complete each assignment. An additional optional assessment of 500 words can also be completed early on in the course so students can get relevant feedback in preparation for their main coursework. The assignment question will be given at the beginning of the course after first introducing the topic.    

Students must submit a completed Declaration of Authorship form at the end of term when submitting your final piece of work. CATS points cannot be awarded without the aforementioned form - Declaration of Authorship form

Application

To earn credit (CATS points) for your course you will need to register and pay an additional £10 fee per course. You can do this by ticking the relevant box at the bottom of the enrolment form or when enrolling online.

Please use the 'Book' or 'Apply' button on this page. Alternatively, please complete an enrolment form (Word) or enrolment form (Pdf).

Level and demands

This is an introduction level course suitable for non-specialist students. No prior course work is required. 

Students who register for CATS points will receive a Record of CATS points on successful completion of their course assessment.

To earn credit (CATS points) you will need to register and pay an additional £10 fee per course. You can do this by ticking the relevant box at the bottom of the enrolment form or when enrolling online.

Coursework is an integral part of all weekly classes and everyone enrolled will be expected to do coursework in order to benefit fully from the course. Only those who have registered for credit will be awarded CATS points for completing work at the required standard.

Students who do not register for CATS points during the enrolment process can either register for CATS points prior to the start of their course or retrospectively from the January 1st after the current full academic year has been completed. If you are enrolled on the Certificate of Higher Education you need to indicate this on the enrolment form but there is no additional registration fee.

Most of the Department's weekly classes have 10 or 20 CATS points assigned to them. 10 CATS points at FHEQ Level 4 usually consist of ten 2-hour sessions. 20 CATS points at FHEQ Level 4 usually consist of twenty 2-hour sessions. It is expected that, for every 2 hours of tuition you are given, you will engage in eight hours of private study.

Credit Accumulation and Transfer Scheme (CATS)